I’ve come up with a very interesting, I’m sure correct thought that expands the far from equilibrium thermodynamic perspective in a very new and interesting realm. So we hopefully will know by now that everything that flows has the ability flowing energy has the ability to create organized structures. We are an example of how after four billion years, that creative energy continues to create. So we’ve talked frequently about the balance between carbohydrate synthesis, which powers differentiated cellular functions and therefore our brain, etc., as opposed to our recycling functions that fix the damages caused when we were burning sugar via the efficient electron transport system. In contrast, when we turn on fat burning, we turn on autophagy, self-eating, in which we eat are damaged pieces. Well, that’s one aspect of reality.
There’s been kind of a little issue in my brain because on the one hand, we have DNA repair systems that are designed to maintain genetic fidelity. And on the other hand, we see this creative nature. Well, it turns out that they’re both fundamentally true and in very interesting ways. We had done experiments years ago and I had a functional lab and I had the most incredible, wonderful student, Christopher Stubbs.
He did some experiments where we were looking at drug resistant cancer cells that are fat burners vs. drug sensitive sugar burners. And we wanted to look at the DNA every parents on since the fat burners are drug resistant and radiation resistant. We expected that we would see an increased level of the repair enzymes in law and in consistency with existing scientific logic. Well, what happened was we found that the base excision repair enzymes that specifically work on repairing radiation damage, really free radical damage in general, because that’s how radiation works. It creates free radicals, just like your metabolism. Anyway, what we found was that a whole host of these fundamental enzymes were absolutely not expressed either on a RNA level or on a protein level in these drug resistant fat burning cancer cells. So that was quite a puzzle. And of course, I assume somehow we’re screwing up. So we sent cells off to other groups, experts that I’ve worked with historically, and they examined the repair enzymes in these cells and found that that’s absolutely through the drug sensitive ones had them the drug resistant ones did not. And this is what ultimately, you know, really fostered a lot of my understanding and thinking as I tried to dissect that puzzle. But now I’ve come to a very interesting new conclusion. So when cells are in their differentiated mode. Burning sugar vier, the combination of the electron transport system that will generate clean, good energy, but also too many free radicals if we overeat or under exercise, basically. So under those conditions, the cell is successfully interacting with its environment, is able to use the flowing energy and in a safe, creative fashion.
However, what happens when we’re fat burning and all of these enzymes are missing? It turns out that there is still a functional repair enzyme system in existence in these fat burning cells. It’s called non homologous enjoining. And the thing that’s so interesting about this is unlike the other repair systems that maintain genetic integrity. This one actually produces diversity and it does so in a very interesting fashion. For example, it can create chromosomal switches so that one chromosome becomes attached to another.
Which means that certain controlling agents can now become under the control of inappropriate things. We see that with Burkett’s lymphoma specifically in Africa, the same illness that causes mono here causes tumors. And it turns out that there’s a recombination event where a heavy chain of our antibody production is now linked up with one of our pro-cancer genes. So not a good situation and has its consequences. The point being, though, that when we turn on fat burning, when we turn on this recycling process, we do that only when the cell is under extreme stress. It basically shuts down communication with this environment and it fixes itself by eating itself, eating its garbage: the free radical damage pieces. And what then occurs what occurs under those circumstances is these recombinational events I’ve spoken in the past, how evolution is targeted that our conventional thinking misses the big picture. Evolution is driven by the flowing energy and its creative nature. And now what I’m trying to explain, hopefully somewhat coherently, is that when cells are happy doing their thing and everything’s in balance, they want to maintain integrity, genetic integrity. However, when things are troublesome, what they’re going to do is focus mutations and change on the genes that are giving survival. So we create diversity. We create the very molecular structures that are the foundation of evolution, gene amplification and mixing pieces of DNA. Yeah, this in particular, non homologous enjoining. So this is very interesting. Fix things when they’re good and diversify things when they’re bad so you can explore the opportunities for survival in the future.